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KMID : 0363320020230010047
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Journal of Korean Oriental Internal Medicine
2002 Volume.23 No. 1 p.47 ~ p.56
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The Effects of Jingansikpung-tang, derived from Anal Therapy on CHT-induced Brian Edema and Neurological Disturbance Symptom in Rats
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Yoon Jun-Chul
Moon Seok-Jae
Moon Goo
Won Jin-Hee
Yoo Kyung-Tae
Moon Young-Ho
Lee Jong-Bum
Kim Hong-Joon
Lee Jong-Deok
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Abstract
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Objectives: We identified the effects of Jingansikpung-tang, (JGSPT), derived from therapy on closed head trama(CHT)-induced brain edema and neurologial disturbance symptom in rats.
Methods : We used a drop device and induced CHT. We divided the animals into 3 groups. They were JGSPT 1 group (Administered JGSPT 96.5mg/kr through anal far one hour after using CHT) and JGSPT 2 group(Administered JGSPT 386mg/kg through anal for one hour after using CHT) Then, we tested neurological severity score(NSS), water content of brain and haematological changes.
Result : aNSS increased significantly in JGSPT 1 and JGSPT 2 as compared to the controlled group, and the change of water content which was pulled out of the right hemisphere from the left hemisphere decreased in JGSPT 1 and JGSPT 2 as compared to the controlled group. The lactate level in serum decreased in JGSPT 1 and JGSPT 2 as compared to the controlled group, which showed no efficacy. Glucose level in serum increased in JGSPT 1 and JGSPT 2 as compared to the controlled group, only JGSPT 2 showed no efficacy.
Conclusions : JGSPT, caused by Anal Therapy and effect on CHT-induced brain edema and neurological symptom.
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KEYWORD
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Jingansikpung-tang, (zhenganxifeng-tang), CHT, Anal Therapy, NSS, brain edema
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